SidaGhanaV1, Main, Exploration, bibRecord, 000983

High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea

Identifieur interne : 000983 ( Main/Exploration ); précédent : 000982; suivant : 000984

High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea

Auteurs : Mpho Magwalivha [Afrique du Sud] ; Marianne Wolfaardt [Afrique du Sud] ; Nicholas M. Kiulia [Kenya] ; Walda B. Van Zyl [Afrique du Sud] ; Jason M. Mwenda [Kenya] ; Maureen B. Taylor [Afrique du Sud]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2010-01.

RBID : ISTEX:66E89F6E10AE2554D436167C43E31982641ED187

Descripteurs français

Wicri :
- geographic : Kenya.
- topic : épidémiologie.

English descriptors

KwdEn :
- Acute gastroenteritis, Adenovirus, Aids patients, Assay, Clin, Clin microbiol, Diarrheal, Diarrheal disease, Diarrheal specimens, Diarrheal stool specimens, Enteric, Enteric hadvs, Epidemiology, Gastroenteritis, Genotype, Hadv, Hadv genotypes, Hadv infection, Hadv prevalence, Hadv species, Hadv strains, Hadvs, Hierholzer, High prevalence, Hospice, Human adenoviruses, Jong, Kenya, Kenyan, Kenyan children, Medical virology, Microbiol, Molecular epidemiology, Northern ghana, Nucleic acid, Nucleotide sequences, Older children, Pediatric, Pediatric patients, Phylogenetic analysis, Pretoria, Prevalence, Rotavirus, Rural area, Rural settings, Serotypes, Stool, Stool specimens, Stool suspension, Urban children, Urban clinics, Urban hospice, Viral, Viral gastroenteritis, Virol, Virology, Young children.
Teeft :
- Acute gastroenteritis, Adenovirus, Aids patients, Assay, Clin, Clin microbiol, Diarrheal, Diarrheal disease, Diarrheal specimens, Diarrheal stool specimens, Enteric, Enteric hadvs, Epidemiology, Gastroenteritis, Genotype, Hadv, Hadv genotypes, Hadv infection, Hadv prevalence, Hadv species, Hadv strains, Hadvs, Hierholzer, High prevalence, Hospice, Human adenoviruses, Jong, Kenya, Kenyan, Kenyan children, Medical virology, Microbiol, Molecular epidemiology, Northern ghana, Nucleic acid, Nucleotide sequences, Older children, Pediatric, Pediatric patients, Phylogenetic analysis, Pretoria, Prevalence, Rotavirus, Rural area, Rural settings, Serotypes, Stool, Stool specimens, Stool suspension, Urban children, Urban clinics, Urban hospice, Viral, Viral gastroenteritis, Virol, Virology, Young children.

Abstract

Human adenoviruses (HAdVs) cause a wide range of clinical syndromes and are classified in seven species, A–G, comprising 52 serotypes. HAdV‐A31, ‐F40, and ‐F41 have been associated with diarrhea in infants and young children. In developing countries gastroenteritis is a major cause of morbidity and mortality in children and, in comparison to rotaviruses, there are no data on the HAdVs associated with diarrhea in pediatric patients in Kenya. This study investigates the prevalence and genotypes of HAdVs in 278 stool specimens (211 diarrheal; 67 non‐diarrheal) from children ≤14 years of age in urban and rural areas in Kenya. Stool specimens were screened for HAdVs using a nested polymerase chain reaction and the HAdVs genotyped by sequence analysis of a conserved hexon gene fragment. HAdVs were detected in 104/278 (37.4%) of the stool specimens: 35/43 (81.4%) of diarrheal and 10/61 (16.4%) of non‐diarrheal stool specimens from children in an urban hospice; 25/94 (26.6%) of diarrheal specimens from urban children and 34/80 (42.5%) of diarrheal specimens from children in a rural area. Species D HAdVs were identified as the most prevalent HAdV species in diarrheal stool specimens from urban children comprising 18/37 (48.6%) of the strains identified. In contrast HAdV species F predominated in pediatric diarrheal specimens from the rural area, being identified in 7/16 (43.8%) of the characterized strains. This study provides valuable new data on the prevalence and distribution of HAdV genotypes in diarrheal stool specimens in Kenya and Africa, and highlights the necessity for further investigations. J. Med. Virol. 82:77–84, 2010. © 2009 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/66E89F6E10AE2554D436167C43E31982641ED187/fulltext/pdf

DOI: 10.1002/jmv.21673

Affiliations:

Afrique du Sud, Kenya

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Le document en format XML

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<term>Clin</term>
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<term>Diarrheal disease</term>
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<term>Gastroenteritis</term>
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<term>Hadv prevalence</term>
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<term>Kenyan</term>
<term>Kenyan children</term>
<term>Medical virology</term>
<term>Microbiol</term>
<term>Molecular epidemiology</term>
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<term>Nucleic acid</term>
<term>Nucleotide sequences</term>
<term>Older children</term>
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<term>Pediatric patients</term>
<term>Phylogenetic analysis</term>
<term>Pretoria</term>
<term>Prevalence</term>
<term>Rotavirus</term>
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<term>Rural settings</term>
<term>Serotypes</term>
<term>Stool</term>
<term>Stool specimens</term>
<term>Stool suspension</term>
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<term>Urban clinics</term>
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<term>Aids patients</term>
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<term>Clin</term>
<term>Clin microbiol</term>
<term>Diarrheal</term>
<term>Diarrheal disease</term>
<term>Diarrheal specimens</term>
<term>Diarrheal stool specimens</term>
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<term>Enteric hadvs</term>
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<term>Gastroenteritis</term>
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<term>Hadv genotypes</term>
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<term>Nucleotide sequences</term>
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<front><div type="abstract" xml:lang="en">Human adenoviruses (HAdVs) cause a wide range of clinical syndromes and are classified in seven species, A–G, comprising 52 serotypes. HAdV‐A31, ‐F40, and ‐F41 have been associated with diarrhea in infants and young children. In developing countries gastroenteritis is a major cause of morbidity and mortality in children and, in comparison to rotaviruses, there are no data on the HAdVs associated with diarrhea in pediatric patients in Kenya. This study investigates the prevalence and genotypes of HAdVs in 278 stool specimens (211 diarrheal; 67 non‐diarrheal) from children ≤14 years of age in urban and rural areas in Kenya. Stool specimens were screened for HAdVs using a nested polymerase chain reaction and the HAdVs genotyped by sequence analysis of a conserved hexon gene fragment. HAdVs were detected in 104/278 (37.4%) of the stool specimens: 35/43 (81.4%) of diarrheal and 10/61 (16.4%) of non‐diarrheal stool specimens from children in an urban hospice; 25/94 (26.6%) of diarrheal specimens from urban children and 34/80 (42.5%) of diarrheal specimens from children in a rural area. Species D HAdVs were identified as the most prevalent HAdV species in diarrheal stool specimens from urban children comprising 18/37 (48.6%) of the strains identified. In contrast HAdV species F predominated in pediatric diarrheal specimens from the rural area, being identified in 7/16 (43.8%) of the characterized strains. This study provides valuable new data on the prevalence and distribution of HAdV genotypes in diarrheal stool specimens in Kenya and Africa, and highlights the necessity for further investigations. J. Med. Virol. 82:77–84, 2010. © 2009 Wiley‐Liss, Inc.</div>
</front>
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High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea

High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri